BET inhibitor CF53
CAS No. 1808160-52-2
BET inhibitor CF53 ( —— )
产品货号. M12767 CAS No. 1808160-52-2
BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3013 | 有现货 |
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10MG | ¥4504 | 有现货 |
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25MG | ¥7258 | 有现货 |
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50MG | ¥9882 | 有现货 |
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100MG | ¥13365 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BET inhibitor CF53
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1).
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产品描述BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1); potently inhibits different BET proteins with Kd values of 0.5-2.2 nM, weakly inhibits CREBBP (Ki=47 nM) and shows excellent selectivity over other bromodomain containing proteins; inhibits cell growth in MOLM-13 and MDA-MB-231 cell lines with IC50 of 7 and 85 nM, respectively; CF53 demonstrates significant antitumor activity in both triple-negative breast cancer and acute leukemia xenograft models in mice.
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同义词——
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通路Chromatin/Epigenetic
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靶点Bromodomain
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受体Bromodomain
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研究领域——
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适应症——
化学信息
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CAS Number1808160-52-2
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分子量443.51
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分子式C24H25N7O2
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纯度>98% (HPLC)
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溶解度DMSO : 110 mg/mL 248.03 mM
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SMILESCC1=C(C(=NO1)C)C2=C(C=C3C(=C2)NC4=C3C(=NC(=N4)C)NC5=CC(=NN5C)C6CC6)OC
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化学全称N-(3-Cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-amine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhao Y, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00483.
产品手册
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